netty-transport-native-epoll is OSGi bundle and can be deployed to OSGi container now: https://github.com/netty/netty/issues/5119
Currently DataStax Driver checks the ability to use netty-transport-native-epoll via Class.forName. In case of OSGi it does not work because netty-transport-native-epoll is a separate bundle and there is no correspondent import in DataStax Driver as OSGi bundle.
This problem can be resolved by adding of DynamicImport-Package or optional imports declaration to DataStax Driver MANIFEST.MF
Added "DynamicImport-Package: *" I got DataStax Driver 3.3.0 + netty-transport-native-epoll (4.0.52.Final) are up and running in OSGi container